Yuxuan Zhang, Gerardo Martin Quindoza III, Hayato Laurence Mizuno,Yasuhiro Nakagawa, Toshiaki Tanaka, Yasutaka Anraku, Toshiyuki Ikoma.
“Preparation of Hydroxyapatite-Aligned Collagen Sheets and TheirEvaluation for Fibroblast Adhesion and Collagen Secretion.” ACS Biomaterials Science & Engineering 11(2), 1072-1083, 2025.
Toshiaki Tanaka*, Koji Moriya, Makoto Tsunenaga, Takayo Yanagawa, Hiromi Morita, Takashi Minowa, Yoh-ichi Tagawa, Nobutaka Hanagata, Yutaka Inagaki, and Toshiyuki Ikoma.Visualized procollagen Ia1 demonstrates the intracellular processing of propeptides.Life Science Alliance 5(5): e202101060, 2022.
K. Moriya, M. Tamai, T. Koga, T. Tanaka, Y. Tagawa. Acetaminophen-induced hepatotoxicity of cultured hepatocytes depends on timing of isolation from light-cycle controlled mice. Genes to Cells25, 257-269, 2020.
K. Kawaguchi, A. Endo, T. Fukushima, Y. Madoka, T. Tanaka, M. Komada. Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion. Biochemical and Biophysical Research Communications499, 635-641, 2018.
Y. Satou, K. Minami, E. Hosono, H. Okada, Y. Yasuoka, T. Shibano, T. Tanaka, M. Taira. Phosphorylation states change Otx2 activity for cell proliferation and patterning in the Xenopus embryo. Development145, dev159640, 2018.
T. Tanaka*, H. Ochi, S. Takahashi, N. Ueno, M. Taira. Genes coding for Cyclin-dependent Kinase Inhibitors are Fragile in Xenopus. Developmental Biology426, 291-300, 2017.
K. Kawaguchi, K. Uo, T. Tanaka, M. Komada. Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25. Scientific Reports7, 45037, 2017.
A. M. Session, Y. Uno, T. Kwon,, T.Tanaka et al.Genome evolution in the allotetraploid frog Xenopus laevis. Nature538, 336–343, 2016.
H. Tanno, T. Shigematsu, S. Nishikawa, A. Hayakawa, K. Denda, T. Tanaka, M. Komada. Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP37. Journal of Biological Chemistry289, 2415-2423, 2014.
X. Li, Y. Bian, Y. Takizawa, T. Hashiomoto, N. Kitamura, T. Ikoma, J. Tanaka, Y. Inagaki, M. Komada, T. Tanaka*. ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression. Molecular Cancer Research11 (11),1437-1447, 2013.
M. Hara, Y. Abe, T. Tanaka, T. Yamamoto, E. Okumura, T. Kishimoto. Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase promoting factor. Nature Communications3, 1059, 2012.
R. Igarashi, T. Sakai, H. Hara, T. Tenno, T. Tanaka, H. Tochio, M.Shirakawa. Distance determination in proteins inside Xenopus laevis oocytes by double electron-electron resonance experiments. Journal of the American Chemical Society132, 8228-8229, 2010.
K. Ushio, T. Hashimoto, N. Kitamura. T. Tanaka*. Id1 is down-regulated by hepatocyte growth factor via ERK-dependent and –independent signaling pathways, leading to increased expression of p16INK4a in hepatoma cells. Molecular Cancer Research7, 1179-1188, 2009.
E. Shirako, N. Hirayama, Y. Tsukada, T. Tanaka*, N. Kitamura*. Up-regulation of p21CIP1 expression mediated by ERK-dependent and –independent pathways contributes to hepatocyte growth factor induced inhibition of HepG2 hepatoma cell proliferation. Journal of Cellular Biochemistry104, 176-188, 2008.
A. Kondo, N. Hirayama, Y. Sugito, M. Shono, T. Tanaka, N. Kitamura. Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. Journal of Biological Chemistry283, 1428-1436, 2008.
J. Han, Y. Tsukada, E. Hara, N. Kitamura, T. Tanaka*. Hepatocyte growth factor induces redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. Journal of Biological Chemistry280, 31548-31556, 2005.
T. Tanaka, M. Kubota, K. Shinohara, K. Yasuda, J-Y. Kato. In vivo analysis of the cyclin D1 promoter during early embryogenesis in Xenopus. Cell Structure and Function28, 165-177, 2003. Picked in Cover Image.
T. Tanaka, T. Ono, N. Kitamura, J-Y. Kato. Dominant negative E2F inhibits progression of the cell cycle after the midblastula transition in Xenopus. Cell Structure and Function28, 515-522, 2003.
@京都大学&奈良科学技術大学院大学
K. Tomoda, Y. Kubota, Y. Arata, S. Mori, M. Maeda, T. Tanaka, N. Yoneda-Kato, J-Y. Kato. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. Journal of Biological Chemistry277, 2302-2310, 2002.
K. Kurokawa, T. Tanaka, J-Y. Kato. p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts. Oncogene18, 2718-2727, 1999.
E. Akamatsu, T. Tanaka, J-Y. Kato. Transcription factor E2F and Cyclin E-Cdk2 complex cooperate to induce chromosomal DNA replication in Xenopus oocytes. Journal of Biological Chemistry273, 16494-16500, 1998.
K. Itahana, T. Tanaka, Y. Morikazu, S. Komatsu, N. Ishida, T. Takeya. Isolation and characterization of a novel connexin gene, Cx-60, in porcine ovarian follicles. Endocrinology139, 320-329, 1998.
T. Tanaka, K. Itahana, N. Ando, T. Takeya, E. Sato. Expression of prostatic secretory protein (PSP)-like protein in porcine corpus luteum: Isolation and characterization of a new gene encoding PSP94-like protein. Molecular Reproduction and Development42, 149-156, 1995.
T. Tanaka, N. Andoh, T. Takeya, E. Sato. Differential screening of ovarian cDNA libraries detected the expression of the porcine collagenase inhibitor gene in functional corpora lutea. Molecular and Cellular Endocrinology83, 65-71, 1992.
@名古屋大学
Y. Takahashi, H. Kuroda, T. Tanaka, Y. Machida, I. Takebe, T. Nagata. Isolation of an auxin-regulated gene cDNA expressed during the transition from G0 to S phase in tabacco mesophyl protoplasts. Proceedings of the National Academy of Sciences of the USA86, 9279-9283, 1989.
第34回国際化粧品技術者会連盟 (IFSCC 2024) 34th congress IFSCC (The International Federation of Societiesof Cosmetic Chemists)
“Changes in type I collagen associated with progression of cellsenescence”
Katsura Sano; Koji Moriya; Yuki Shibaike; Toshiaki Tanaka
2024年10月15-17日 Iguazu Falls@Brazil
第46回日本分子生物学会年会 シンポジウム: 細胞外マトリックスから見た老化研究
「細胞老化に伴うコラーゲン線維とコラーゲンプロセシング過程変化の可視化I型プロコラーゲンを用いた解析」
“Analysis of collagen fibril formation and its processing step associated with progression of cell senescence using visualized type I procollagen” 田中利明、芝池由樹、佐野桂、守矢恒司 2023年12月6日(会期6-9日) @神戸ポートピアホテル
Venture Café Tokyo, Thursday Gathering #248 Tokyo Tech Startup Night (TTGF Demo day)
「可視化I型コラーゲンにより科学的に機能が証明されたコラーゲン分泌促進成分・素材と体内コラーゲンマーカー開発」 田中利明 <オーディエンス賞受賞>
2023年6月29日 @CIC Tokyo(虎ノ門ヒルズビジネスセンター)
GTIE DEMO day FY2022「Applied Biomatrix 起業プロジェクト」 田中利明 2023年3月3日 @渋谷スクランブルスクエア
https://gtie-demo-day-fy2022.peatix.com/
GTIE プレデモデイシンポジウム 招待講演 「可視化 I 型コラーゲンの社会実装」 田中利明 2022年11月30日 @慶應大 三田キャンパス北館ホールもしくはオンラインhttps://peatix.com/event/3404834
第12回化粧品開発展 アカデミックフォーラム 「可視化I型コラーゲンによる分泌評価と成分/薬剤スクリーニング」
“Visualized type I Collagen enables evaluation of the secretion and screening of regulatory factors” 田中利明 2022年01月12日(会期12-14日) @東京ビッグサイト
BioJapan 2019
「可視化技術による I 型コラーゲン生合成のライブイメージング」
(Visualization of processing and secretion of type I collagen by live imaging) 田中利明
2019 年 10月10日(会期9-11 日) @パシフィコ横浜
International Symposium on Genome Science.
“What we can do with over 300 billion bases of RNA-seq data: The case of Xenopus laevis genome project.”
T. Kwon, S. Takahashi, T. Tanaka, H. Noguchi, A. Toyoda., A. Fujiyama, Y. Suzuki, N. Ueno, M. Taira, J. B. Wallingford, E. M. Marcotte. 2013年1月9日 @The University of Tokyo, Ito International Research Center, Japan.
会議発表(2016年以降)
第84回癌学会学術集会 口頭発表
Cancer-associated fibroblasts in “Immature” DR promote colorectal cancercell behavior via type I procollagen processing
Immature型の線維性癌間質反応を形成するCAFsはI型プロコラーゲンのプロセシングを介して大腸癌細胞の遊走と増殖に関与する
Yuki Sota1), Satsuki Mochizuki1), Koji Moriya1), Toshiaki Tanaka2),Kenta Kikuya1), Keita Tashiro1), Masato Yamadera1), Koichi Okamoto1),Yoshiki Kajiwara1), Yoji Kishi1), Yasunori Okada3), Hideki Ueno
2025年9月25-27日 @石川県立音楽堂、ホテル日航金沢、ANAクラウンプラザホテル金沢 他
Collagen Conference 2025 Gordon Research Conference
“Cell-based evaluation system of C-propeptide cleavage using visualized type I procollagen α1” Koji Moriya, Satsuki Mochizuki, Hideki Ueno, Toshiaki Tanaka
2025年7月6-11日@ Colby-Sawyer College, New Hampshire, USA
2023 Joint meeting of The American Society for Matrix Biology (ASMB), The Histochemical Society (HCS), and the American Society for Investigative Pathology (ASIP) ポスター発表 Koji Moriya, Toshiaki Tanaka
“Quantification of C-pp processing and collagen secretion by visualized type I procollagen α1.”
22. October (会期 22-25. October)@The Grand America Hotel in Salt Lake City, Utah
STAC-12 (The 12th International Conference on the Science and Technology for Advanced Ceramics, 国際学会)口頭発表
“Synthesis and characterization of Hydroxyapatite Hollow Nanoparticles for DNA Delivery Vehicles.”
中川泰宏、錦織桜子、守矢恒司、田中利明、生駒俊之
2021年7月6日~8日 @オンライン開催
29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine.
Bioceramics 29 (Poster)
“Hollow mesoporous silica particles with large pores for encapsulation of drugs.”
M. Iwatsuka, T. Ikoma, T. Tanaka.
2017 年 8月25-27日 @Touoluse, France.